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Key residues for the light-regulation of the blue light activated adenylyl cyclase (bPAC) from Beggiatoa sp.

Stierl, Manuela ; Penzkofer, Alfons ; Kennis, J. T. M. ; Hegemann, Peter ; Mathes, Tilo


Photoactivated adenylyl cyclases are powerful tools for optogenetics and for investigating signal transduction mechanisms in biological photoreceptors. Because of its large increase in enzyme activity in the light, the BLUF (blue light sensor using flavin adenine dinucleotide)-activated adenylyl cyclase (bPAC) from Beggiatoa sp. is a highly attractive model system for studying BLUF domain ...


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