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The Synthetic alpha-Bromo-2’,3,4,4’-tetramethoxychalcone (alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway

Pinz, Sophia, Unser, Samy, Brueggemann, Susanne, Besl, Elisabeth, Al-Rifai, Nafisah, Petkes, Hermina, Amslinger, Sabine and Rascle, Anne (2014) The Synthetic alpha-Bromo-2’,3,4,4’-tetramethoxychalcone (alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway. PLoS ONE 9, e90275.

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Date of publication of this fulltext: 17 Oct 2014 11:55

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Other URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090275


Abstract

Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for malignant transformation. We describe here the identification of the synthetic chalcone ...

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Item type:Article
Date:2014
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0090275DOI
Keywords:TYROSINE KINASE INHIBITOR; DNA-BINDING ACTIVITY; NF-KAPPA-B; TRANSACTIVATION DOMAIN; LEUKEMIA-CELLS; CONSTITUTIVE ACTIVATION; SERINE PHOSPHORYLATION; HEMATOPOIETIC-CELLS; STAT5 ACTIVATION; GENE-EXPRESSION
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30896
Owner only: item control page

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