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The Synthetic alpha-Bromo-2’,3,4,4’-tetramethoxychalcone (alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway

URN to cite this document:
Pinz, Sophia ; Unser, Samy ; Brueggemann, Susanne ; Besl, Elisabeth ; Al-Rifai, Nafisah ; Petkes, Hermina ; Amslinger, Sabine ; Rascle, Anne
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 17 Oct 2014 11:55


Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for malignant transformation. We describe here the identification of the synthetic chalcone ...


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