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Vgamma9Vdelta2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromo¬some 6

Riaño, F. ; Karunakaran, M. M. ; Starick, L. ; Li, J. ; Scholz, C. J. ; Kunzmann, V. ; Olive, D. ; Amslinger, Sabine ; Herrmann, T.



Abstract

Pyrophosphorylated metabolites of isoprenoid-biosynthesis (phosphoantigens, PAgs) activate Vγ9Vδ2 T cells during infections and trigger antitumor activity. This activation depends on expression of butyrophilin 3 A1 (BTN3A1) by antigen-presenting cells. This report defines the minimal genetic requirements for activation of Vγ9Vδ2 T cells by PAgs and mAb 20.1. We compared PAg-presentation by ...

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