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Epstein-Barr virus (EBV)-host cell interactions: an epigenetic dialogue?

Niller, Hans Helmut, Minarovits, Janos and Szenthe, Kalman (2014) Epstein-Barr virus (EBV)-host cell interactions: an epigenetic dialogue? Epigenomics and Epigenetics.

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Date of publication of this fulltext: 20 Oct 2014 11:29

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Other URL: http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00367/abstract


Abstract

Epstein-Barr virus (EBV) is associated with diverse lymphoid and epithelial malignancies. Their molecular pathogenesis is accompanied by epigenetic alterations which are distinct for each of them. While lymphoblastoid cell lines (LCLs) derived from B cells transformed by EBV in vitro are characterized by a massive demethylation and euchromatinization of the viral and cellular genomes, the ...

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Item type:Article
Date:2 October 2014
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fgene.2014.00367DOI
Keywords:Chromatin, CpG island, DNA Methylation, viral latency, lytic cycle, methylome, oncoprotein, pioneer transcription factor, tumour suppressor gene, tumour virus
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30908
Owner only: item control page

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