Epstein-Barr virus (EBV)-host cell interactions: an epigenetic dialogue?

URN to cite this document:: urn:nbn:de:bvb:355-epub-309085
DOI to cite this document:: 10.5283/epub.30908

Niller, Hans Helmut ; Minarovits, Janos ; Szenthe, Kalman

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Date of publication of this fulltext: 20 Oct 2014 11:29

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Abstract

Epstein-Barr virus (EBV) is associated with diverse lymphoid and epithelial malignancies. Their molecular pathogenesis is accompanied by epigenetic alterations which are distinct for each of them. While lymphoblastoid cell lines (LCLs) derived from B cells transformed by EBV in vitro are characterized by a massive demethylation and euchromatinization of the viral and cellular genomes, the ...