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Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes

Leyh, Michaela, Seitz, Andreas, Dürselen, Lutz, Schaumburger, Jens, Ignatius, Anita, Grifka, Joachim and Grässel, Susanne (2014) Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. Arthritis Research & Therapy 16 (453).

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Date of publication of this fulltext: 04 Nov 2014 17:08

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Other URL: http://arthritis-research.com/content/16/5/453


Abstract

Introduction Osteoarthritis (OA) is characterized by an imbalance in cartilage and underlying subchondral bone homeostasis. We hypothesized that signals from the subchondral bone may modulate production of matrix components, alter chondrogenic differentiation potential of cocultured bone marrow-derived mesenchymal stem cells (BMSC) and induce a phenotypic shift in differentiated OA ...

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Item type:Article
Date:7 October 2014
Institutions:Medicine > Lehrstuhl für Orthopädie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s13075-014-0453-9DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30930
Owner only: item control page

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