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Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

Brandes, Franziska, Schmidt, Katharina Maria, Wagner, Christine, Redekopf, Julia, Schlitt, Hans-Jürgen, Geissler, Edward K. and Lang, Sven A. (2015) Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model. BMC Cancer 15 (71), pp. 1-14.

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Date of publication of this fulltext: 19 Feb 2015 13:41

at publisher (via DOI)

Other URL: http://www.biomedcentral.com/1471-2407/15/71/abstract


Abstract

Background Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in pancreatic cancer models in vitro and in vivo. Methods Human (L3.6pl, BxP3, HPAF-II, MiaPaCa2) and murine (Panc02) pancreatic cancer cell lines, endothelial cells (ECs) and ...

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Item type:Article
Date:19 February 2015
Institutions:Medicine > Lehrstuhl für Chirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12885-015-1064-9DOI
Keywords:Pancreatic cancer, cMET, Resistance, Survival
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31355
Owner only: item control page

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