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Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

URN to cite this document:
urn:nbn:de:bvb:355-epub-313551
Brandes, Franziska ; Schmidt, Katharina Maria ; Wagner, Christine ; Redekopf, Julia ; Schlitt, Hans-Jürgen ; Geissler, Edward K. ; Lang, Sven A.
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Date of publication of this fulltext: 19 Feb 2015 13:41


Abstract

Background Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in pancreatic cancer models in vitro and in vivo. Methods Human (L3.6pl, BxP3, HPAF-II, MiaPaCa2) and murine (Panc02) pancreatic cancer cell lines, endothelial cells (ECs) and ...

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