Go to content
UR Home

XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis

URN to cite this document:
urn:nbn:de:bvb:355-epub-313608
Ehrenschwender, Martin ; Bittner, S. ; Seibold, K. ; Wajant, Harald
[img]
Preview
PDF
(2MB)
Date of publication of this fulltext: 20 Feb 2015 13:33


Abstract

Mutations in the oncogenic PIK3CA gene are found in 10–20% of colorectal cancers (CRCs) and are associated with poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic TRAIL death receptor antibodies emerged as promising anti-neoplastic therapeutics, but to date failed to prove their capability in the clinical setting as especially primary tumors exhibit high ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons