XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-313608
DOI to cite this document:: 10.5283/epub.31360

Ehrenschwender, Martin ; Bittner, S. ; Seibold, K. ; Wajant, Harald

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Date of publication of this fulltext: 20 Feb 2015 13:33

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Abstract

Mutations in the oncogenic PIK3CA gene are found in 10–20% of colorectal cancers (CRCs) and are associated with poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic TRAIL death receptor antibodies emerged as promising anti-neoplastic therapeutics, but to date failed to prove their capability in the clinical setting as especially primary tumors exhibit high ...