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Interleukin 21 controls tumor growth and tumor immunosurveillance in colitis-associated tumorigenesis in mice

Jauch, Dominik (2015) Interleukin 21 controls tumor growth and tumor immunosurveillance in colitis-associated tumorigenesis in mice. PhD, Universität Regensburg.

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Date of publication of this fulltext: 12 Mar 2015 16:50

Abstract (English)

Colitis-associated tumorigenesis is a balance between proliferation of tumour cells and tumour immunosurveillance. The role of T-helper cell-derived cytokines in tumour growth is not fully understood. In this study the authors investigated the influence of Interleukin (IL) 21 on intestinal tumorigenesis. Chronic colitis was induced in IL-21-/- and littermate control wild-type mice with three ...

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Translation of the abstract (German)

Die Kolitis-assoziierte Tumorenstehung wird durch ein Gleichgewicht von Tumorzellwachstum und zellvermittelter Tumorbekämpfung bestimmt. Die Funktion von T-Helfer-Zell Zytokinen ist in der Tumorentstehung bislang noch nicht hinreichend geklärt. In dieser Arbeit untersuchten wir den Einfluss von Interleukin (IL) 21 auf die intestinale entzündungsassoziierte Tumorentstehung. Eine chronische Kolitis ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:12 March 2015
Referee:Prof. Dr. Stefan Fichtner-Feigl
Date of exam:10 March 2015
Institutions:Medicine > Lehrstuhl für Chirurgie
Keywords:Interleukin 21, Kolitis-assoziierte Tumorentstehung, Tumor-Immunosurveillance
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31452
Owner only: item control page

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