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Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)

URN to cite this document:
urn:nbn:de:bvb:355-epub-314977
Weber, Bernhard H. F. ; Bergholz, Richard ; Mändl, Julia ; Jägle, Herbert ; Ruether, Klaus ; Grassmann, Felix
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Date of publication of this fulltext: 20 Mar 2015 11:53


Abstract

Background Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk factors are duration and dosage of treatment while the involvement of genetic factors contributing to ...

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