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Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)

Weber, Bernhard H. F. , Bergholz, Richard, Mändl, Julia, Jägle, Herbert, Ruether, Klaus and Grassmann, Felix (2015) Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). BMC Ophthalmology 15 (18), pp. 1-7.

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Date of publication of this fulltext: 20 Mar 2015 11:53

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Other URL: http://www.biomedcentral.com/1471-2415/15/18


Abstract

Background Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk factors are duration and dosage of treatment while the involvement of genetic factors contributing to ...

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Item type:Article
Date:6 March 2015
Institutions:Medicine > Lehrstuhl für Humangenetik
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12886-015-0008-0DOI
Keywords:Chloroquine induced maculopathy; ABCA4; Age-related macular degeneration; Stargardt’s disease; Genetic association
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31497
Owner only: item control page

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