Go to content
UR Home

Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function

Rascle, Anne, Pinz, Sophia, Unser, Samy, Buob, Dominik, Fischer, Philipp and Jobst, Belinda (2015) Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. Nucleic Acids Research 2015 (1), pp. 1-22.

[img]
Preview
PDF
Download (2MB)
Date of publication of this fulltext: 20 Mar 2015 15:06

at publisher (via DOI)

Other URL: http://nar.oxfordjournals.org/content/early/2015/03/12/nar.gkv188.full


Abstract

Signal transducer and activator of transcription STAT5 is essential for the regulation of proliferation and survival genes. Its activity is tightly regulated through cytokine signaling and is often upregulated in cancer. We showed previously that the deacetylase inhibitor trichostatin A (TSA) inhibits STAT5-mediated transcription by preventing recruitment of the transcriptional machinery at a ...

plus


Export bibliographical data



Item type:Article
Date:13 March 2015
Institutions:Medicine > Lehrstuhl für Immunologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1093/nar/gkv188DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31505
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons