Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function

URN to cite this document:: urn:nbn:de:bvb:355-epub-315056
DOI to cite this document:: 10.5283/epub.31505

Rascle, Anne ; Pinz, Sophia ; Unser, Samy ; Buob, Dominik ; Fischer, Philipp ; Jobst, Belinda

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Date of publication of this fulltext: 20 Mar 2015 15:06

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Abstract

Signal transducer and activator of transcription STAT5 is essential for the regulation of proliferation and survival genes. Its activity is tightly regulated through cytokine signaling and is often upregulated in cancer. We showed previously that the deacetylase inhibitor trichostatin A (TSA) inhibits STAT5-mediated transcription by preventing recruitment of the transcriptional machinery at a ...