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Die Rolle des Transkriptionsfaktors ZBTB16 bei der osteogenen Differenzierung dentaler Follikelzellen

Felthaus, Oliver Heinrich (2015) Die Rolle des Transkriptionsfaktors ZBTB16 bei der osteogenen Differenzierung dentaler Follikelzellen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 26 Mar 2015 15:18

Abstract (German)

Dentale Follikelzellen (Dental Follicle Cells, DFCs) lassen sich durch Stimulation mit den Wachstumsfaktoren BMP2 (Bone Morphogenetic Protein 2) oder IGF2 (Insulin-like Growth Factor 2) sowie dem Glucocorticoid Dexamethason osteogen differenzieren. Während alle drei Induktoren geeignet sind, die Steigerung der ALP (Alkalische Phosphatase)-Aktivität und die Bildung einer mineralisierten Matrix zu ...

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Translation of the abstract (English)

Dental follicle cells (DFCs) can be differentiated into the osteogenic lineage by stimulation with growth factors BMP2 or IGF2 or the glucocorticoid dexamethasone. Treatment with either of theses induces an increased ALP activity and a mineralization, but upregulation of typical osteogenic marker genes like the transcription factor RUNX2 can be observed after treatment with BMP2 or IGF2, only. ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:26 March 2015
Referee:Prof. Dr. Gottfried Schmalz
Date of exam:16 October 2014
Institutions:Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie
Keywords:mesenchymale Stammzellen, osteogene Differenzierung, Transkriptionsfaktor ZBTB16
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31520
Owner only: item control page

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