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Combinatorial Liquid-Phase Synthesis of [1,4]oxazepine-7-ones via the Baylis-Hillman Reaction

Räcker, Reinhard ; Döring, Klaus ; Reiser, Oliver



Abstract

A new method for the synthesis of [1,4]oxazepin-7-ones from readily available aldehydes and -amino alcohols was developed using the Baylis-Hillman reaction as the key step. To determine the scope and limitations of the method, a mixture library was synthesized from six aldehydes and six -amino alcohols on the soluble polymer support poly(ethylene glycol) 5000 monomethyl ether (MeOPEG) via split ...

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