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EGR1 supports the osteogenic differentiation of dental stem cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-316412
Preß, Thomas
Date of publication of this fulltext: 20 Apr 2015 12:39


Abstract (English)

Aim: To evaluate whether and how the transcription factor early growth response gene 1 (EGR1) affects the osteogenic differentiation of dental stem cells. Methology: Dental stem cells from apical papilla (SCAPs) and from the dental follicle (DFCs) were transfected with EGR1 specific siRNA or EGR-1 expression plasmid. Gene regulation was verified at protein level by Western blotting. The ...

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Translation of the abstract (German)

Fragestellung: Beeinflusst early growth response gene 1 (EGR1) die osteogene Differenzierung in dentalen Stammzellen und wenn ja, was sind die möglichen Mechanismen dahinter? Methodik: Dentale Stammzellen der apikalen Papille (SCAP) und dentale Follikelzellen (DFC) wurden mit einer EGR1-spezifischen siRNA oder einem EGR1-Expressionsplasmid transfiziert. Die Expression osteogener Markergene wurde ...

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