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In Vitro Induction of Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier by Isoflurane but Not by Sevoflurane and Midazolam

Dittmar, Michael S., Petermichl, Walter, Lindner, Regina, Sinner, Barbara, Graf, Bernhard M., Schlachetzki, Felix and Gruber, Michael (2015) In Vitro Induction of Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier by Isoflurane but Not by Sevoflurane and Midazolam. PLoS ONE 10 (6), pp. 1-13.

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Date of publication of this fulltext: 05 Aug 2015 15:47

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Other URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130408


Abstract

Background The effects of anesthetics on the injured brain continue to be the subject of controversial discussion. Since isoflurane has recently been shown to induce apoptosis of cerebral endothelial cells, this study compared different anesthetic compounds regarding their potential to induce cerebro-vascular apoptosis. Methods The in vitro model of the blood-brain barrier used in this study ...

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Item type:Article
Date:19 June 2015
Institutions:Medicine > Lehrstuhl für Anästhesiologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0130408DOI
Article ID: e0130408Other
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32313
Owner only: item control page

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