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In Vitro Induction of Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier by Isoflurane but Not by Sevoflurane and Midazolam

URN to cite this document:
Dittmar, Michael S. ; Petermichl, Walter ; Lindner, Regina ; Sinner, Barbara ; Graf, Bernhard M. ; Schlachetzki, Felix ; Gruber, Michael
Date of publication of this fulltext: 05 Aug 2015 15:47


Background The effects of anesthetics on the injured brain continue to be the subject of controversial discussion. Since isoflurane has recently been shown to induce apoptosis of cerebral endothelial cells, this study compared different anesthetic compounds regarding their potential to induce cerebro-vascular apoptosis. Methods The in vitro model of the blood-brain barrier used in this study ...


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