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Human Argonaute proteins: Analysis of endonucleolytic activity and endogenous phosphorylation sites

Hauptmann, Judith (2016) Human Argonaute proteins: Analysis of endonucleolytic activity and endogenous phosphorylation sites. PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Dec 2016 08:58

Abstract (English)

Argonaute (Ago) proteins interact with small non-coding RNAs, which guide them to complementary target RNAs to mediate gene silencing. The domain organization of Ago proteins clearly reflects their function. The ends of the small RNA are bound by the Mid and PAZ domains and the structure of the PIWI domain closely resembles that of the endonuclease RNase H. Indeed, some Ago proteins can cleave ...

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Translation of the abstract (German)

Argonaute-(Ago-)Proteine interagieren mit kleinen, nicht-codierenden RNAs, welche sie zu komplementären Ziel-RNAs leiten, um Genrepression zu vermitteln. Die Domänenorganisation von Ago-Proteinen spiegelt deren Funktion deutlich wider. Die Enden der kleinen RNA werden durch die Mid- und PAZ-Domänen gebunden und die Struktur der PIWI-Domäne ähnelt stark der der Endonuklease RNase H. Tatsächlich ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:19 December 2016
Referee:Prof. Dr. Gunter Meister
Date of exam:19 June 2015
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Keywords:Argonaute proteins, Ago-APP, Argonaute modification, Argonaute phosphorylation
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32323
Owner only: item control page

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