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Deprotection of N-alloc amines by Pd(0) /DABCO: an efficient method for in situ peptide coupling of labile amino acids

Zorn, Chiara ; Gnad, Frieder ; Salmen, Sunnhild ; Herpin, Timothy ; Reiser, Oliver


A highly efficient one-pot deprotection/peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (10–20 min) and allowing the coupling of amino acids that are unstable in unprotected forms.

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