Deprotection of N-alloc amines by Pd(0) /DABCO: an efficient method for in situ peptide coupling of labile amino acids

Abstract

A highly, efficient one-pot deprotection peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (10 20 min) and allowing the coupling of amino acids that are unstable in unprotected forms. (C) 2001 Elsevier Science Ltd. All rights reserved.