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Dissection of piRNA precursor biogenesis and the epigenetic mechanisms of the piRNA pathway

Stuwe, Evelyn (2015) Dissection of piRNA precursor biogenesis and the epigenetic mechanisms of the piRNA pathway. PhD, Universität Regensburg.

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Date of publication of this fulltext: 01 Oct 2015 16:32

Abstract (English)

RNA interference (RNAi) is a cellular mechanism where small RNAs (20 to 35 nucleotides in length) pair with proteins to build effector complexes guiding them to RNA targets through homologous base pairing. The piRNA pathway is a germ line specific RNAi pathway that protects the gonads of animals from harmful genetic sequences, termed transposable elements (TEs). TEs are viral DNA remnants that ...

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Translation of the abstract (German)

RNA Interferenz (RNAi) beschreibt die Regulierung von RNA Moleküle durch einen Komplex, bestehend aus kleinen nicht-codierenden RNAs und einem Protein der Argonauten Familie. In diesem Komplex dient die kleine nicht-kodierende RNA der Erkennung der Ziel-RNA über komplementäre Basenpaarung, während Argonatuen die Expression der Ziel-RNA modulieren. Der piRNA Pathway ist ein RNAi Mechanismus, der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:September 2015
Referee:Prof. Dr. Gunter Meister
Date of exam:24 July 2015
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Keywords:piRNA, Drosophila, transposable elements
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32468
Owner only: item control page

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