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Multivalent nanoparticles bind the retinal and choroidal vasculature

Hennig, Robert ; Ohlmann, Andreas ; Staffel, Janina ; Pollinger, Klaus ; Haunberger, Alexandra ; Breunig, Miriam ; Schweda, Frank ; Tamm, Ernst R. ; Goepferich, Achim


The angiotensin II receptor type 1 (AT1R), which is expressed in blood vessels of the posterior eye, is of paramount significance in the pathogenesis of severe ocular diseases such as diabetic retinopathy and age-related macular degeneration. However, small molecule angiotensin receptor blockers (ARBs) have not proven to be a significant therapeutic success. We report here on a nanoparticle ...


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