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Multivalent nanoparticles bind the retinal and choroidal vasculature

Hennig, Robert, Ohlmann, Andreas, Staffel, Janina, Pollinger, Klaus, Haunberger, Alexandra, Breunig, Miriam, Schweda, Frank, Tamm, Ernst R. and Goepferich, Achim (2015) Multivalent nanoparticles bind the retinal and choroidal vasculature. Journal of Controlled Release 220 (Part A), pp. 265-274.

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Abstract

The angiotensin II receptor type 1 (AT1R), which is expressed in blood vessels of the posterior eye, is of paramount significance in the pathogenesis of severe ocular diseases such as diabetic retinopathy and age-related macular degeneration. However, small molecule angiotensin receptor blockers (ARBs) have not proven to be a significant therapeutic success. We report here on a nanoparticle ...

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Item type:Article
Date:2015
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.jconrel.2015.10.033DOI
Keywords:Multivalency; EXP3174; Quantum dots; Age-related macular degeneration; Diabetic retinopathy; Angiotensin II
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32730
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