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The Endocannabinoid System Exerts Anti-Inflammatory and Pro-Apoptotic Effects on Synovial Fibroblasts in Rheumatoid Arthritis

Apitz, Martin (2015) The Endocannabinoid System Exerts Anti-Inflammatory and Pro-Apoptotic Effects on Synovial Fibroblasts in Rheumatoid Arthritis. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Nov 2015 13:54

Abstract (German)

Die Rheumatoide Arthritis ist eine häufige Autoimmunerkrankung, die 0,5-1 % der erwachsenen Bevölkerung betrifft und als chronische Gelenkentzündung zu fortschreitender Gelenkzerstörung und systemischen Symptomen wie z.B. das metabolisches Syndrom und Atherosklerose führt. In den letzten Jahrzehnten wurde das pathogenetische Verständnis der Rheumatoiden Arthritis auf Nicht-Immunzellen erweitert. ...

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Translation of the abstract (English)

Rheumatoid arthritis affect about 0.5-1 % of adults. It eventually leads to joint degeneration and systemic inflammation with comorbidities such as metabolic syndrome or atherosclerosis. The past research revealed non-immunological cells to be part of the pathogenetic mechanism. Fibroblast-like synoviocytes are the key aggressive players in rheumatoid arthritis and largely responsible for ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:24 November 2015
Referee:Prof. Dr. Rainer H. Straub and Prof. Dr. Dr. Joachim Grifka
Date of exam:10 November 2015
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Keywords:Endocannabinoidsystem, Rheumatoide Arthritis, Fibroblasten
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32795
Owner only: item control page

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