The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation

URN to cite this document:: urn:nbn:de:bvb:355-epub-328135
DOI to cite this document:: 10.5283/epub.32813

Loedige, Inga ; Jakob, Leonhard ; Treiber, Thomas ; Ray, Debashish ; Stotz, Mathias ; Treiber, Nora ; Hennig, Janosch ; Cook, Kate B. ; Morris, Quaid ; Hughes, Timothy R. ; Engelmann, Julia C. ; Krahn, Michael P. ; Meister, Gunter

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Date of publication of this fulltext: 16 Nov 2015 14:57

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Abstract

TRIM-NHL proteins are conserved among metazoans and control cell fate decisions in various stem cell linages. The Drosophila TRIM-NHL protein Brain tumor (Brat) directs differentiation of neuronal stem cells by suppressing self-renewal factors. Brat is an RNA-binding protein and functions as a translational repressor. However, it is unknown which RNAs Brat regulates and how RNA-binding ...