Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis

URN to cite this document:: urn:nbn:de:bvb:355-epub-329228
DOI to cite this document:: 10.5283/epub.32922

Grässel, Susanne ; Muschter, Dominique ; Schäfer, Nicole ; Stangl, Hubert ; Straub, Rainer H.

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Date of publication of this fulltext: 26 Nov 2015 13:37

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Abstract

Excessive synovial osteoclastogenesis is a hallmark of rheumatoid arthritis (RA). Concomitantly, local synovial changes comprise neuronal components of the peripheral sympathetic nervous system. Here, we wanted to analyze if collagen-induced arthritis (CIA) alters bone marrow-derived macrophage (BMM) osteoclastogenesis and osteoclast activity, and how sympathetic neurotransmitters participate in ...