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The Cytoprotective Effects of E-α-(4-Methoxyphenyl)-2’,3,4,4'-Tetramethoxychalcone (E-α-p-OMe-C6H4-TMC)-A Novel and Non-Cytotoxic HO-1 Inducer

Kaufmann, Kai B., Al-Rifai, Nafisah, Ulbrich, Felix, Schallner, Nils, Rücker, Hannelore, Enzinger, Monika, Petkes, Hermina, Pitzl, Sebastian, Goebel, Ulrich and Amslinger, Sabine (2015) The Cytoprotective Effects of E-α-(4-Methoxyphenyl)-2’,3,4,4'-Tetramethoxychalcone (E-α-p-OMe-C6H4-TMC)-A Novel and Non-Cytotoxic HO-1 Inducer. PLoS ONE 10 (11), e0142932.

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Date of publication of this fulltext: 30 Nov 2015 14:16

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Other URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142932


Abstract

Cell protection against different noxious stimuli like oxidative stress or chemical toxins plays a central role in the treatment of many diseases. The inducible heme oxygenase isoform, heme oxygenase-1 (HO-1), is known to protect cells against a variety of harmful conditions including apoptosis. Because a number of medium strong electrophiles from a series of α-X-substituted ...

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Item type:Article
Date:2015
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0142932DOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:32925
Owner only: item control page

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