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The Cytoprotective Effects of E-α-(4-Methoxyphenyl)-2’,3,4,4'-Tetramethoxychalcone (E-α-p-OMe-C6H4-TMC)-A Novel and Non-Cytotoxic HO-1 Inducer

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Kaufmann, Kai B. ; Al-Rifai, Nafisah ; Ulbrich, Felix ; Schallner, Nils ; Rücker, Hannelore ; Enzinger, Monika ; Petkes, Hermina ; Pitzl, Sebastian ; Goebel, Ulrich ; Amslinger, Sabine
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Date of publication of this fulltext: 30 Nov 2015 14:16


Cell protection against different noxious stimuli like oxidative stress or chemical toxins plays a central role in the treatment of many diseases. The inducible heme oxygenase isoform, heme oxygenase-1 (HO-1), is known to protect cells against a variety of harmful conditions including apoptosis. Because a number of medium strong electrophiles from a series of α-X-substituted ...


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