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Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data

Lottaz, Claudio and Spang, Rainer (2005) Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data. Bioinformatics 21 (9), pp. 1971-1978.

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Abstract

MOTIVATION: Today, the characterization of clinical phenotypes by gene-expression patterns is widely used in clinical research. If the investigated phenotype is complex from the molecular point of view, new challenges arise and these have not been addressed systematically. For instance, the same clinical phenotype can be caused by various molecular disorders, such that one observes different ...

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Item type:Article
Date:25 January 2005
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
10.1093/bioinformatics/bti292DOI
15677704PubMed ID
Keywords:"Databases, Genetic", "Gene Expression Profiling", "Genetic Testing", "Humans", "Natural Language Processing", "Neoplasm Proteins", "Neoplasms", "Oligonucleotide Array Sequence Analysis", "Phenotype", "Reproducibility of Results", "Sensitivity and Specificity", "Structure-Activity Relationship", "Tumor Markers, Biological"
Dewey Decimal Classification:000 Computer science, information & general works > 004 Computer science
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32951
Owner only: item control page

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