A co-culture model of fibroblasts and adipose tissue-derived stem cells reveals new insights into impaired wound healing after radiotherapy

URN to cite this document:: urn:nbn:de:bvb:355-epub-329657
DOI to cite this document:: 10.5283/epub.32965

Haubner, Frank ; Mutscher, Dominique ; Pohl, Fabian ; Schreml, Stephan ; Prantl, Lukas ; Gassner, Holger G.

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Date of publication of this fulltext: 02 Dec 2015 16:06

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Abstract

External radiation seems to be associated with increased amounts of cytokines and other cellular modulators. Impaired microcirculation and fibrosis are examples of typical long term damage caused by radiotherapy. Adipose tissue-derived stem cells (ASC) are discussed to enhance wound healing, but their role in wounds due to radiotherapy is poorly understood. Normal human fibroblasts (NHF) and ASCs ...