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Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner

Lowin, Torsten, Apitz, Martin, Anders, Sven and Straub, Rainer H. (2015) Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. Arthritis Research & Therapy 17 (321), pp. 1-14.

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Date of publication of this fulltext: 11 Dec 2015 17:49

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Other URL: http://www.arthritis-research.com/content/17/1/321


Abstract

Introduction The endocannabinoid system modulates function of immune cells and mesenchymal cells such as fibroblasts, which contribute to cartilage destruction in rheumatoid arthritis (RA). The aim of the study was to determine the influence of N-acylethanolamines anandamide (AEA), palmitoylethanolamine (PEA) and oleylethanolamine (OEA) on several features of arthritic inflammation in vitro ...

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Item type:Article
Date:14 November 2015
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s13075-015-0845-5DOI
Keywords:Synoviocytes; Tumor necrosis factor; Interleukin 6; Interleukin 8; Synovial fibroblasts; TRPV1; TRPA1; Cannabinoids; Anandamide; Matrix metalloproteinase 3; Collagen-induced arthritis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33048
Owner only: item control page

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