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TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception

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Wetzel, Christian H. ; Jendryke, Thomas ; Prochazkova, Michaela ; Hall, Bradford E. ; Nordmann, Gregory C. ; Schladt, Moritz ; Milenkovic, Vladimir M. ; Kulkarni, Ashok B.
Date of publication of this fulltext: 23 Mar 2016 07:45


TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to hyperalgesia and allodynia. We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat). Increasing or decreasing Cdk5 ...


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