TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception

URN to cite this document:: urn:nbn:de:bvb:355-epub-334586
DOI to cite this document:: 10.5283/epub.33458

Wetzel, Christian H. ; Jendryke, Thomas ; Prochazkova, Michaela ; Hall, Bradford E. ; Nordmann, Gregory C. ; Schladt, Moritz ; Milenkovic, Vladimir M. ; Kulkarni, Ashok B.

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Date of publication of this fulltext: 23 Mar 2016 07:45

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Abstract

TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to hyperalgesia and allodynia. We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat). Increasing or decreasing Cdk5 ...