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TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception

Wetzel, Christian H., Jendryke, Thomas, Prochazkova, Michaela, Hall, Bradford E., Nordmann, Grégory C., Schladt, Moritz, Milenkovic, Vladimir M. and Kulkarni, Ashok B. (2016) TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Scientific Reports 6 (22007), pp. 1-15.

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Date of publication of this fulltext: 23 Mar 2016 07:45

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Other URL: http://www.nature.com/articles/srep22007


Abstract

TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to hyperalgesia and allodynia. We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat). Increasing or decreasing Cdk5 ...

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Item type:Article
Date:23 February 2016
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/srep22007DOI
Article ID: 22007Other
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33458
Owner only: item control page

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