Wetzel, Christian H., Jendryke, Thomas, Prochazkova, Michaela, Hall, Bradford E., Nordmann, Grégory C., Schladt, Moritz, Milenkovic, Vladimir M. and Kulkarni, Ashok B. (2016) TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Scientific Reports 6 (22007), pp. 1-15.
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Other URL: http://www.nature.com/articles/srep22007
Abstract
TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to hyperalgesia and allodynia. We present behavioral and molecular data indicating that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat). Increasing or decreasing Cdk5 ...
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| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Date: | 23 February 2016 | ||||||
| Institutions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften | ||||||
| Projects: | Open Access Publizieren (DFG) | ||||||
| Identification Number: |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 33458 |
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