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Funktionelle Analyse des ATP13A2 Orthologs in D. melanogaster

Heßner, Sabina (2017) Funktionelle Analyse des ATP13A2 Orthologs in D. melanogaster. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Aug 2017 05:41

Abstract (German)

Das Kufor-Rakeb Syndrom ist eine juvenile Form von Parkinson, die autosomal rezessiv vererbt wird. Über 20 verschiedene Mutationen wurden im betroffenen Gen ATP13A2 (PARK9) bisher gefunden. Es codiert für eine P5B-ATPase, bei der die Substratspezifität noch nicht geklärt ist. Die vorliegende Dissertation beschäftigt sich mit der Analyse des Orthologs von ATP13A2 im Modellorganismus Drosophila ...

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Translation of the abstract (English)

Parkinson is the second most common neurodegenerative disease in the world. Most of the cases are idiopathic forms and only 5-10% have a genetic reason. The Kufor-Rakeb syndrome is one of the hereditary forms of Parkinsonism with juvenile onset and is caused by mutations in the gene ATP13A2 (PARK9). PARK9 encodes for a P5B-ATPAse with unknown substrate specificity. In this thesis the Drosophila ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:3 August 2017
Referee:Prof. Dr. Stephan Schneuwly
Date of exam:3 February 2016
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Keywords:Kufor-Rakeb Syndrom, ATP13A2, Drosophila, Lysosomen, dopaminerge Neuronen, Metalltoxizität
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33585
Owner only: item control page

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