Go to content
UR Home

Funktionelle Analyse des ATP13A2 Orthologs in D. melanogaster

Heßner, Sabina (2017) Funktionelle Analyse des ATP13A2 Orthologs in D. melanogaster. PhD, Universität Regensburg.

License: Publishing license for publications excluding print on demand
Download (6MB)
Date of publication of this fulltext: 03 Aug 2017 05:41

Abstract (German)

Das Kufor-Rakeb Syndrom ist eine juvenile Form von Parkinson, die autosomal rezessiv vererbt wird. Über 20 verschiedene Mutationen wurden im betroffenen Gen ATP13A2 (PARK9) bisher gefunden. Es codiert für eine P5B-ATPase, bei der die Substratspezifität noch nicht geklärt ist. Die vorliegende Dissertation beschäftigt sich mit der Analyse des Orthologs von ATP13A2 im Modellorganismus Drosophila ...


Translation of the abstract (English)

Parkinson is the second most common neurodegenerative disease in the world. Most of the cases are idiopathic forms and only 5-10% have a genetic reason. The Kufor-Rakeb syndrome is one of the hereditary forms of Parkinsonism with juvenile onset and is caused by mutations in the gene ATP13A2 (PARK9). PARK9 encodes for a P5B-ATPAse with unknown substrate specificity. In this thesis the Drosophila ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:3 August 2017
Referee:Prof. Dr. Stephan Schneuwly
Date of exam:3 February 2016
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Keywords:Kufor-Rakeb Syndrom, ATP13A2, Drosophila, Lysosomen, dopaminerge Neuronen, Metalltoxizität
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 590 Zoological sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33585
Owner only: item control page


Downloads per month over past year

  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons