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In situ and in vitro profiling of brain tumour initiating cells of high-grade gliomas

Leidgens, Verena Jeannine (2016) In situ and in vitro profiling of brain tumour initiating cells of high-grade gliomas. PhD, Universität Regensburg.

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Date of publication of this fulltext: 12 May 2016 11:50

Abstract (English)

High-grade gliomas, especially glioblastomas, are highly complex and heterogeneous primary brain tumours. Glioblastoma (GBM) is one of the most aggressive cancers with poor overall survival prognosis. Fast and widespread invasion of the brain parenchyma by a subpopulation of progenitor tumour cells is a main pathophysiological feature of these tumours. Invasion renders localised therapies ...

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Translation of the abstract (German)

Höhergradige Gliome, im besonderen Glioblastome sind sehr komplexe, heterogene hirneigene Tumore. Glioblastome zählen zu den aggressivsten Krebsformen mit einer sehr schlechten Prognose. Ein pathophysiologisches Hauptmerkmal ist die schnelle und weit ausgedehnte Invasion des Hirnparenchyms durch eine Subpopulation von Tumorvorläuferzellen. Diese infiltrierenden Tumorzellen stehen im Zusammenhang ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:12 May 2016
Referee:Prof. Peter Hau
Date of exam:8 April 2016
Institutions:Medicine > Lehrstuhl für Neurologie
Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Keywords:Glioblastoma, GBM, brain tumor initiating cells, BTIC, STAT3, ibuprofen, diclofenac
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33757
Owner only: item control page

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