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Functional analysis of genetic variants associated with age-related macular degeneration (AMD) - The HtrA serine peptidase 1 (HTRA1)

Datta, Shyamtanu (2016) Functional analysis of genetic variants associated with age-related macular degeneration (AMD) - The HtrA serine peptidase 1 (HTRA1). PhD, Universität Regensburg.

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Date of publication of this fulltext: 13 Jun 2016 11:21

Abstract (English)

Background. Age-related macular degeneration (AMD) is a multifactorial retinal neurodegenerative disorder and the leading cause of blindness among the elderly worldwide. Genetics is one of several factors which play role in the pathogenesis. An AMD-risk locus on chromosome 10q26 spans two genes namely age-related maculopathy susceptibility 2 (ARMS2) and high temperature requirement factor A1 ...

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Translation of the abstract (German)

Hintergrund. Die altersbedingte Makuladegeneration (AMD) ist eine multifaktorielle retinale neurodegenerative Erkrankung und die häufigste Ursache für Erblindung bei älteren Menschen weltweit. Genetik ist einer von mehreren Faktoren, die eine Rolle in der Pathogenese spielen. Ein AMD-Risiko-Locus auf Chromosom 10q26 erstreckt sich über zwei Gene, age-related maculopathy susceptibility 2 (ARMS2) ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:13 June 2016
Referee:Prof. Dr. Bernhard Weber
Date of exam:10 June 2016
Institutions:Medicine > Lehrstuhl für Humangenetik
Keywords:AMD, HTRA1, TGF-β1, microglia
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33773
Owner only: item control page

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