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Visible light amination/Smiles cascade: access to
phthalazine derivatives

URN to cite this document:
urn:nbn:de:bvb:355-epub-338428
Brachet, Etienne ; Marzo, Leyre ; Selkti, Mohamed ; König, Burkhard ; Belmont, Philippe
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Date of publication of this fulltext: 01 Jun 2016 07:48


Abstract

We report the synthesis of various phthalazines via a new cascade reaction, initiated by visible light photocatalysis, involving a radical hydroamination reaction followed by a radical Smiles rearrangement. Phthalazine derivatives are obtained in high yields and from a broad scope readily accessible orthoalkynylsulfonohydrazone precursors. The mild photoredox conditions ensure an excellent ...

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