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Refining Pathways: A Model Comparison Approach

Moffa, Giusi, Erdmann, Gerrit, Voloshanenko, Oksana, Hundsrucker, Christian, Sadeh, Mohammad Javad, Boutros, Michael and Spang, Rainer (2016) Refining Pathways: A Model Comparison Approach. PLoS One 11 (6), e0155999.

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Date of publication of this fulltext: 16 Jun 2016 07:15

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Other URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155999


Cellular signalling pathways consolidate multiple molecular interactions into working models of signal propagation, amplification, and modulation. They are described and visualized as networks. Adjusting network topologies to experimental data is a key goal of systems biology. While network reconstruction algorithms like nested effects models are well established tools of computational biology, ...


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Item type:Article
Date:1 June 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Projects:Open Access Publizieren (DFG)
Identification Number:
27248690PubMed ID
Keywords:Wnt signalling cascade; Secretion; Colorectal cancer; Antigen-presenting cells; Gene expression; Gene regulation; Signaling networks; Topology
Dewey Decimal Classification:000 Computer science, information & general works > 004 Computer science
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:33870
Owner only: item control page


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