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Refining Pathways: A Model Comparison Approach

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Moffa, Giusi ; Erdmann, Gerrit ; Voloshanenko, Oksana ; Hundsrucker, Christian ; Sadeh, Mohammad Javad ; Boutros, Michael ; Spang, Rainer
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Date of publication of this fulltext: 16 Jun 2016 07:15


Cellular signalling pathways consolidate multiple molecular interactions into working models of signal propagation, amplification, and modulation. They are described and visualized as networks. Adjusting network topologies to experimental data is a key goal of systems biology. While network reconstruction algorithms like nested effects models are well established tools of computational biology, ...


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