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Sulphated Oligosaccharides as Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus agalactiae.

Salmen, Sunnhild ; Hoechstetter, Julia ; Käsbauer, Christian ; Paper, Dieter H. ; Bernhardt, Günther ; Buschauer, Armin



Abstract

Potent and specific inhibitors of hyaluronidases, a group of enzymes preferentially catalysing the hydrolysis of hyaluronic acid, are not known so far. Such compounds could be useful as pharmacological tools for studying the physiological and pathophysiological role of both hyaluronan and hyaluronidases. The effects of sulphated and non-sulphated structurally different oligosaccharides on bovine ...

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