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Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor,

Seifert, Roland ; Wenzel-Seifert, Katharina ; Bürckstümmer, Tilmann ; Pertz, Heinz H. ; Schunack, Walter ; Dove, Stefan ; Buschauer, Armin ; Elz, Sigurd



Abstract

Species isoforms of histamine H-2-, H-3-, and H-4-receptors differ in their pharmacological properties. The study aim was to dissect differences between the human H1R (hH(1)R) and guinea pig H1R (ghH(1)R). We coexpressed hH(1)R and gpH(1)R with regulators of G-protein signaling in Sf9 insect cells and analyzed the GTPase activity of G(q)-proteins. Small H1R agonists showed similar effects at ...

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