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Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods,

Schuster, Andreas ; Götte, Carsten ; Bernhardt, Günther ; Buschauer, Armin



Abstract

Analytical CE and HPLC methods were developed for the chiral separation of halogen-substituted 3-phenyl-3-(2-pyridyl)propylamines 1-4 (1: 3-(4-fluorophenyl), 2: 3-(3,4-difluorophenyl), 3: 3-(4-chlorophenyl), 4: 3-(3,4-dichlorophenyl)), 3-(4-fluorophenyl)-3-(2-thiazolyl)propylamine (5), and 3-(4-fluorophenyl)-3-(1-benzylimidazol-2-yl)propylamine (6), which are building blocks for the preparation ...

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