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Indirect inference of synergistic and alternative signalling of intracellular pathways

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Pirkl, Martin Franz-Xaver
Date of publication of this fulltext: 27 Jul 2016 08:55

Abstract (English)

In this work we introduce Boolean Nested Effects Models (B-NEM). B-NEM combines the indirect inference on signalling pathways of the original Nested Effects Models (NEM) with the logical modelling of the CellNet Optimizer. The pathway molecules are called signalling genes (S-genes). These S-genes can be perturbed, e.g. stimulated or inhibited. These perturbations effect the transcription and ...


Translation of the abstract (German)

In dieser Arbeit stellen wir Boolean Nested Effects Models (B-NEM) vor. B-NEM kombiniert die indirekte Inferenz der originalen Nested Effects Models auf Signalwege mit dem logischen Model des CellNet Optimizers. Die Moleküle im Signalweg werden Signalgene (S-gene) genannt. Diese S-gene können beeinflusst werden, z.B. durch Stimulation oder Unterdrückung. Diese Beeinflussung hat Auswirkungen auf ...


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