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Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer

Rascle, Anne, Pinz, Sophia and Unser, Samy (2016) Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer. BMC Molecular Biology 17 (10), pp. 1-11.

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Date of publication of this fulltext: 28 Jul 2016 15:09

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Other URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831086/


Abstract

Background c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been identified so far within the c-Myc gene locus, therefore a direct transcriptional regulation by STAT5 remains uncertain. c-Myc super-enhancer, located 1.7 Mb downstream of the c-Myc gene locus, was recently reported as essential for ...

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Item type:Article
Date:14 April 2016
Institutions:Medicine > Lehrstuhl für Immunologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12867-016-0063-yDOI
Keywords:STAT5, c-Myc, BET, BRD2, Super-enhancer, Chromatin
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34167
Owner only: item control page

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