Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer

URN to cite this document:: urn:nbn:de:bvb:355-epub-341677
DOI to cite this document:: 10.5283/epub.34167

Rascle, Anne ; Pinz, Sophia ; Unser, Samy

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Date of publication of this fulltext: 28 Jul 2016 15:09

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Abstract

Background: c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been identified so far within the c-Myc gene locus, therefore a direct transcriptional regulation by STAT5 remains uncertain. c-Myc super-enhancer, located 1.7 Mb downstream of the c-Myc gene locus, was recently reported as essential for ...