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Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)

Weber, Bernhard H. F. , Grassmann, Felix, Cantsilieris, Stuart, Schulz-Kuhnt, Anja-Sabrina, White, Stefan J., Richardson, Andrea J., Hewitt, Alex W., Vote, Brendan J., Schmied, Denise, Guymer, Robyn H. and Baird, Paul N. (2016) Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD). Jornal of Neuroinflammation 13 (81), pp. 1-9.

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Date of publication of this fulltext: 28 Jul 2016 15:31

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Other URL: http://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0548-0


Abstract

Background Age-related macular degeneration (AMD) is the leading cause of vision loss in Western societies with a strong genetic component. Candidate gene studies as well as genome-wide association studies strongly implicated genetic variations in complement genes to be involved in disease risk. So far, no association of AMD with complement component 4 (C4) was reported probably due to the ...

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Item type:Article
Date:18 April 2016
Institutions:Medicine > Lehrstuhl für Humangenetik
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12974-016-0548-0DOI
Keywords:Age-related macular degeneration; AMD; C4; Complement; Copy number variation (CNV); Multiallelic; Genetic association
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34168
Owner only: item control page

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