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Kinetic analysis of renin and its inhibitors by detecting double-labelled peptidic substrates with an immunoassay

Gorris, H.H. (2013) Kinetic analysis of renin and its inhibitors by detecting double-labelled peptidic substrates with an immunoassay. Analyst 138, pp. 2104-2109.

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Date of publication of this fulltext: 04 Aug 2016 08:23

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Abstract

The proteolytic activity of renin is a key element in the regulation of blood pressure and a main target for inhibitor design. Currently, the activity of renin and its inhibitors is mainly analyzed using radioimmunoassays or FRET-substrates, which both have their limitations. Here, a novel kinetic assay is presented that combines the advantages of a homogeneous proteolytic reaction and a robust ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Identification Number:
ValueType
10.1039/c3an36508eDOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34241
Owner only: item control page

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