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Kinetic analysis of renin and its inhibitors by detecting double-labelled peptidic substrates with an immunoassay

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Gorris, H. H.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 04 Aug 2016 08:23


The proteolytic activity of renin is a key element in the regulation of blood pressure and a main target for inhibitor design. Currently, the activity of renin and its inhibitors is mainly analyzed using radioimmunoassays or FRET-substrates, which both have their limitations. Here, a novel kinetic assay is presented that combines the advantages of a homogeneous proteolytic reaction and a robust ...


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