| Published Version Download ( PDF | 1MB) | License: Allianz- bzw. Nationallizenz |
Owner only: item control page
Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties
Dulla, Balakrishna, Kirla, Krishna T.
, Rathore, V., Deora, G. S. , Kavela, S., Maddika, S., Chatti, K. , Reiser, Oliver , make_name_string expected hash reference and make_name_string expected hash reference
(2013)
Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties.
Organic & Biomolecular Chemistry 11, 3103- 3107.
Date of publication of this fulltext: 04 Aug 2016 11:21
Article
DOI to cite this document: 10.5283/epub.34243
Abstract
A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition.
Alternative links to fulltext
Involved Institutions
Details
| Item type | Article | ||||
| Journal or Publication Title | Organic & Biomolecular Chemistry | ||||
| Publisher: | ROYAL SOC CHEMISTRY | ||||
|---|---|---|---|---|---|
| Open Access Type: | Alliance-/National licence | ||||
| Place of Publication: | CAMBRIDGE | ||||
| Volume: | 11 | ||||
| Page Range: | 3103- 3107 | ||||
| Date | 2013 | ||||
| Institutions | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser | ||||
| Identification Number |
| ||||
| Keywords | HISTONE DEMETHYLASE LSD1; ANALOGS; RECEPTOR; REEXPRESSION; INACTIVATOR; CHROMATIN; GENES; | ||||
| Dewey Decimal Classification | 500 Science > 540 Chemistry & allied sciences | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-342433 | ||||
| Item ID | 34243 |
Export bibliographical data
Owner only: item control page
Download Statistics
Download Statistics