Safety and efficacy of defibrotide for the treatment of severe hepatic veno-occlusive disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-344519
DOI to cite this document:: 10.5283/epub.34451

Richardson, Paul M. ; Ho, Vincent T. ; Giralt, Sergio ; Arai, Sally ; Mineishi, Shin ; Cutler, C. ; Antin, Joseph H. ; Stavitzski, N. ; Niederwieser, N. ; Holler, Ernst

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Date of publication of this fulltext: 24 Aug 2016 12:12

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Abstract

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a potentially life-threatening complication of chemotherapeutic conditioning used in preparation for hematopoietic stem-cell transplantation (SCT). VOD may occur in up to 62% of patients undergoing SCT, with onset generally within the first month after SCT. In severe cases, 100-day mortality is in excess of ...