Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-344718
DOI to cite this document:: 10.5283/epub.34471

Männel, Daniela N. ; Schmidt, Dominic ; Peterlik, Daniel ; Reber, Stefan Oskar ; Lechner, Anja

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Date of publication of this fulltext: 25 Aug 2016 09:07

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Abstract

To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress. CSC substantially affected the cell composition of the bone marrow, blood, and spleen by inducing myelopoiesis and enhancing the frequency of regulatory T cells in the CD4 population. Expansion ...