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Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

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Männel, Daniela N. ; Schmidt, Dominic ; Peterlik, Daniel ; Reber, Stefan Oskar ; Lechner, Anja
Date of publication of this fulltext: 25 Aug 2016 09:07


To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress. CSC substantially affected the cell composition of the bone marrow, blood, and spleen by inducing myelopoiesis and enhancing the frequency of regulatory T cells in the CD4 population. Expansion ...


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