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Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response

Nevels, Michael, Harwardt, Thomas, Lukas, Simone, Zenger, Marion, Reitberger, Tobias, Danzer, Daniela, Übner, Theresa, Munday, Diane C. and Paulus, Christina (2016) Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathogens 12 (7), e1005748.

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Date of publication of this fulltext: 31 Aug 2016 14:55

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Other URL: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005748


Abstract

The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced to express IE1 exhibit global repression of IL6- and oncostatin M-responsive STAT3 target genes. ...

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Item type:Article
Date:7 July 2016
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.ppat.1005748DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34494
Owner only: item control page

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