Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression

URN to cite this document:: urn:nbn:de:bvb:355-epub-345795
DOI to cite this document:: 10.5283/epub.34579

Wegener, G. ; Finger, B. ; Elfving, B. ; Keller, K. ; Liebenberg, N. ; Fischer, C. W. ; Singewald, N. ; Slattery, David A. ; Neumann, Inga D. ; Mathé, A. A.

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Date of publication of this fulltext: 06 Oct 2016 14:41

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Abstract

Neuropeptide S (NPS) and its receptor (NPSR) have been implicated in the mediation of anxiolytic-like behaviour in rodents. However, little knowledge is available regarding the NPS system in depression-related behaviours, and whether NPS also exerts anxiolytic effects in an animal model of psychopathology. Therefore, the aim of this work was to characterize the effects of NPS on depression- and ...