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Influence of PEGylation on nanoparticle mobility in different models of the extracellular matrix

Tomasetti, Luise, Liebl, Renate, Wastl, Daniel S. and Breunig, Miriam (2016) Influence of PEGylation on nanoparticle mobility in different models of the extracellular matrix. European Journal of Pharmaceutics and Biopharmaceutics 108, pp. 145-155.

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Abstract

Nanoparticle transport inside the extracellular matrix (ECM) is a crucial factor affecting the therapeutic success. In this work, two in vitro ECM models – a neutrally charged collagen I network with an effective pore size of 0.47 μm and Matrigel, a basement membrane matrix with strong negative charge and effective pore size of 0.14 μm – were assessed for barrier function in the context of ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ejpb.2016.08.007DOI
Keywords:Mobility; ECM; PEGylation density; Nanoparticles; Collagen; Matrigel; Surface charge; Interaction
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34582
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