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Intrinsic and extrinsic determinants of central nervous system axon outgrowth into alginate-​based anisotropic hydrogels

Pawara, Kiran ; Prang, Peter ; Müller, Rainer ; Caioni, Massimiliano ; Bogdahn, Ulrich ; Kunz, Werner ; Weidner, Norbert



Abstract

Appropriate target reinnervation and functional recovery after spinal cord injury depend on longitudinally directed regrowth of injured axons. Anisotropic alginate-based capillary hydrogels (ACH) support peripheral nervous system derived axon growth, which is accompanied by glial supporting cell migration into the ACH. The aim of the present study was to analyze central nervous system (CNS) ...

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