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The role of tumor-derived lactic acid in immunomodulation

Brand, Almut (2016) The role of tumor-derived lactic acid in immunomodulation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Sep 2016 06:53

Abstract (English)

Tumors show alterations in their metabolism to fulfill the requirements of excessive proliferation. The most prominent metabolic change is the switch from OXPHOS to aerobic glycolysis, termed Warburg effect. The increased uptake of glucose, subsequent conversion of pyruvate to lactate and the export of lactate in co-transport with protons lead to the extracellular accumulation of lactic acid and ...

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Translation of the abstract (German)

Tumoren weisen verschiedene Veränderungen in ihrem Stoffwechsel auf. Der Warburg-Effekt, die wohl bedeutendste metabolische Veränderung, ist durch gesteigerte aerobe glykolytische Aktivität charakterisiert. Hierbei wird vermehrt Glukose in die Zelle aufgenommen und zu Laktat umgewandelt. Dieses wird im Co-Transport mit Protonen aus der Zelle ausgeschleust, was zu einer Anreicherung von Laktat und ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:15 September 2016
Referee:Prof. Dr. Marina Kreutz
Date of exam:28 July 2016
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Keywords:tumor immunology; tumor metabolism; lactic acid; lactate; T cells; NK cells; tumor immunosurveillance; immune escape; melanoma; Warburg effect; aerobic glycolysis; Ldha; LDH-5; IFN-γ; immunomodulation
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34607
Owner only: item control page

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