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Cell-type specific responses to antidepressants
- the epigenetic makeup of the glia-neuron interface

Malik, Victoria (2017) Cell-type specific responses to antidepressants
- the epigenetic makeup of the glia-neuron interface.
PhD, Universität Regensburg.

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Date of publication of this fulltext: 07 Nov 2017 13:18

Abstract (English)

Understanding the neurobiological underpinnings of major depressive disorder (MDD) is of utmost importance. Recently, it was shown in post-mortem tissue of MDD patients that the number of glia cells is reduced, accompanied by atrophy of neuronal cells and a decreased volume of the prefrontal cortex (PFC). Following the observation that morphological deficits are present in both cell-types, it is ...

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Translation of the abstract (German)

Es ist äußert wichtig die neurobiologischen Grundlagen einer Depression zu verstehen. Erst kürzlich konnte in postmortalem Gewebe gezeigt werden, dass depressive Patienten eine geringere Anzahl an Gliazellen, neuronale Atrophie sowie ein vermindertes Volumen des präfrontalen Kortex aufweisen. Da morphologische Veränderungen in diesen beiden Zelltypen auftreten ist es sehr wahrscheinlich, dass ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:7 November 2017
Referee:Prof. Dr. Inga D. Neumann and Dr. Barbara Di Benedetto
Date of exam:4 November 2016
Institutions:UNSPECIFIED
Keywords:Glia-neuron interaction, Epigenetic, depression
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34812
Owner only: item control page

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