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NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids

Simeth, Nadja Anita , Bause, Manuel, Dobmeier, Michael, Kling, Ralf C., Lachmann, Daniel, Hübner, Harald, Einsiedel, Jürgen, Gmeiner, Peter and König, Burkhard (2017) NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids. Bioorganic & Medicinal Chemistry 1, pp. 350-359.

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Abstract

Stimulation of the NTS2 neurotensin receptor causes antipsychotic effects and leads to a promotion of the l-opioid-independent antinociception, which is important in the modulation of tonic pain sensitivity. We report the synthesis and properties of a small library of peptidic agonists based on the active neurotensin fragment NT(8-13). Two tetrahydrofuran amino acid derivatives were synthesized ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1016/j.bmc.2016.10.039DOI
Keywords:PHASE PEPTIDE-SYNTHESIS; RECEPTOR-BINDING; FUNCTIONAL EXPRESSION; LIGAND-BINDING; G-PROTEIN; ANALOGS; CANCER; AFFINITY; SITE; BIODISTRIBUTION; Neurotensin; Peptides; Non-natural amino acid
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34836
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