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Determination of the activity of maleimide-functionalized phospholipids during preparation of liposomes

Oswald, Mira, Geissler, Simon and Goepferich, Achim (2016) Determination of the activity of maleimide-functionalized phospholipids during preparation of liposomes. International Journal of Pharmaceutics 514, pp. 93-102.

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Abstract

Numerous examples exist in the literature for the use of maleimide-thiol-reactions in the area of functionalized nanoparticles. Although the hydrolysis tendency of maleimides is well-known, qualitative and quantitative information on the stability and reactivity of maleimide groups during preparation and in final formulations are missing. This is surprising, since hydrolysis of maleimides ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ijpharm.2016.06.116DOI
Keywords:Maleimide activity; Liposomes; DSPE-PEG2000-Mal
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34838
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