Molecular dissection of the valproic acid effects on glioma cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-348714
DOI to cite this document:: 10.5283/epub.34871

Riemenschneider, Markus J. ; Hoja, Sabine ; Schulze, Markus ; Rehli, Michael ; Proescholdt, Martin A. ; Herold-Mende, Christel ; Hau, Peter

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Date of publication of this fulltext: 22 Nov 2016 10:10

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Abstract

Many glioblastoma patients suffer from seizures why they are treated with antiepileptic agents. Valproic acid (VPA) is a histone deacetylase inhibitor that apart from its anticonvulsive effects in some retrospective studies has been suggested to lead to a superior outcome of glioblastoma patients. However, the exact molecular effects of VPA treatment on glioblastoma cells have not yet been ...